Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Along with its needed effects, a medicine may cause some unwanted effects. Pediatric patients: There have been cases of hepatotoxicity, including fatalities, in pediatric patients with juvenile rheumatoid arthritis. Along with its needed effects, indomethacin may cause some unwanted effects. NSAIDs can also cause an increased risk of serious gastrointestinal (GI) adverse events, including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. NSAIDs cause an increased risk of serious gastrointestinal adverse events, including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. It is estimated that most common side effects associated with an intake of Indomethacin include headache, vertigo, dizziness, drowsiness, heartburn, indigestion, tinnitus, nausea and vomiting. You may report side effects to the FDA at 1-800-FDA-1088. I have been taking this medication for a long time and I can report that the positive sides are much bigger than the side effects which I didn’t have. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Last updated on Sep 13, 2020. Other side effects include: dizziness, dyspepsia, hyponatremia, and nausea. Portions of this document last updated: Feb. 01, 2021. Itching 4. Furthermore, the medication may cause diarrhea or constipation together with abdominal pain. These events can occur at any time during use and without warning symptoms. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Tell your doctor if you experience unlikely but serious side effects of Indocin (indomethacin) and Indocin IV (indomethacin) for Injection including swelling of the hands or feet , sudden or unexplained weight gain, hearing changes (such as ringing in the ears), mental/mood changes, difficult/painful swallowing, or unusual tiredness. Krystina Wagner. Discontinue … Merck & Co, Inc, West Point, PA. 3. All rights reserved. She has spent the last 10 years working for an internationally recognized medical facility where she found her passion for making complicated topics easier to … Why is my poop green? Other side effects include:dizziness, dyspepsia, hyponatremia, and nausea. Commonly reported side effects of indomethacin include: headache. Side effects are reported by people who take Indomethacin. Temporary Redness Of Face And Neck 8. Indomethacin blocks the enzymes that … [Ref], Uncommon (0.1% to 1%): Hematuria, vaginal bleeding, proteinuria, breast enlargement/tenderness, gynecomastia, Frequency not reported: Urinary frequency, Very common (10% or more): Oliguria (44%), Frequency not reported: Transient oliguria[Ref], Frequency not reported: Bleeding/oozing from skin following needle puncture[Ref], Uncommon (0.1% to 1%): Muscle weakness, involuntary muscle movements, Frequency not reported: Hypercreatininemia, acceleration of cartilage degeneration[Ref], Uncommon (0.1% to 1%): Dyspnea, acute respiratory distress, asthma, pulmonary edema, epistaxis, Frequency not reported: Bronchospasm, pulmonary eosinophilia, alveolitis, Frequency not reported: Pulmonary hemorrhage, pneumothorax, pulmonary hypertension, apnea, exacerbation of preexisting pulmonary infection[Ref], 1. Indomethacin is a nonsteroidal anti-inflammatory drug that reduces fever, pain and inflammation. The phase IV clinical study is created by eHealthMe based on 11,123 reports from the FDA, and is updated regularly. These side effects may go away during treatment as your body adjusts to the medicine. . Indocin (Indomethacin) Side Effects By. Indomethacin prescription and dosage sizes information for physicians and healthcare professionals. [Ref], Uncommon (0.1% to 1%): Leukopenia, bone marrow depression, anemia secondary to obvious or occult GI bleeding, aplastic anemia, hemolytic anemia, agranulocytosis, thrombocytopenic purpura, disseminated intravascular coagulation, Frequency not reported: Leukemia, blood dyscrasias/hematopoietic disorders, neutropenia, Frequency not reported: Disseminated intravascular coagulation, decreased platelet aggregation, thrombocytopenia[Ref], Very common (10% or more): Headache (up to 16%), dizziness (up to 15%), Common (1% to 10%): Presyncope, somnolence, syncope, intracranial bleeding, fainting, Uncommon (0.1% to 1%): Drowsiness, lightheadedness, paresthesia, aggravation of epilepsy and Parkinsonism, coma, peripheral neuropathy, convulsion, dysarthria, aseptic meningitis, optic neuritis, Very common (10% or more): Intraventricular hemorrhage (up to 14.3%), intracranial hemorrhage (up to 10.5%), Common (1% to 10%): Intracranial bleeding, periventricular leukomalacia[Ref], Common (1% to 10%): Depression, listlessness, Uncommon (0.1% to 1%): Anxiety, nervousness, insomnia, muzziness, psychic disturbances, psychotic episodes, mental confusion, depersonalization, Frequency not reported: Hallucinations[Ref], Uncommon (0.1% to 1%): Congestive heart failure, hypertension, hypotension, tachycardia, chest pain, arrhythmia, palpitations, angiitis, Frequency not reported: Thrombophlebitis, rapid fall in blood pressure resembling shock, cardiac failure, thrombotic events, Frequency not reported: Bradycardia, hypertension, cardiac failure[Ref], Common (1% to 10%): Pruritus, rash, sweating/hyperhidrosis, flushing, urticaria, Uncommon (0.1% to 1%): Petechiae, ecchymosis, exfoliative dermatitis, erythema nodosum, loss of hair/alopecia, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, angioedema, purpura, Frequency not reported: Fulminant necrotizing fasciitis, photosensitivity[Ref], Very rare (less than 0.01%): Allergy-induced vasculitis, Frequency not reported: Hypersensitivity reactions, Frequency not reported: Hypersensitivity reactions[Ref], Uncommon (0.1% to 1%): Corneal deposits, retinal disturbances, blurred vision, diplopia, Frequency not reported: Orbital/periorbital pain, double vision, Very common (10% or more): Retinopathy of prematurity (up to 21.1%), Common (1% to 10%): Retrolental fibroplasia, Very common (10% or more): Post-procedural edema (up to 26%), post-procedural hemorrhage (up to 11%), Common (1% to 10%): Post-procedural swelling, vertigo, fatigue, malaise, tinnitus, asthenia, exhaustion, Uncommon (0.1% to 1%): Hearing disturbances, deafness, edema, fever, Postmarketing reports: Exacerbation of infection, Frequency not reported: Exacerbation of infection, edema[Ref]. What Is Indocin SR? [Ref], Uncommon (0.1% to 1%): Toxic hepatitis, jaundice, elevated ALT/AST, Frequency not reported: Cholestasis, abnormal liver function[Ref], In controlled clinical trials, renal dysfunction occurred statistically significantly more frequently during IV use in neonates than in those treated with placebo. Schedule your appointment now for safe in-person care. 2. Elderly patients are at greater risk for serious gastrointestinal events. Elderly patients and patients with a prior history of peptic ulcer disease and/or GI bleeding are at a greater risk for serious GI events. Side Effects. Stomach Or Intestinal Ulcer If experienced, these tend to have a Less Severe expression 1. Indomethacin is contraindicated in the setting of CABG surgery. Indomethacin (Oral Route) Print. Indocin (indomethacin)." Information from various medical literature states that 44% of infants treated with this drug had oliguria. Common side effects include drug hypersensitivity among females and drug ineffective among males. Indomethacin 25 mg Tablet is used for the treatment of pain, swelling, and inflammation associated with conditions such as osteoarthritis, rheumatoid arthritis, gout, and ankylosing spondylitis. Generally, indomethacin is used to address the symptoms of swelling and joint pain in osteoarthritis or rheumatoid arthritis. Although not all of these side effects may occur, if they do occur they may need medical attention. O 0. This content does not have an Arabic version. Medically reviewed by Drugs.com. Check with your doctor immediately if any of the following side effects occur while taking indomethacin: Get emergency help immediately if any of the following symptoms of overdose occur while taking indomethacin: Some side effects of indomethacin may occur that usually do not need medical attention. It's available only as oral liquid drugs and can serve as rectal-suppository medication. Side effects of indomethacin injection in infants are uncommon, but may include: bleeding; coagulation problems; renal failure . Ringing In The Ears 6. O 0. Data sources include IBM Watson Micromedex (updated 2 Feb 2021), Cerner Multum™ (updated 3 Feb 2021), ASHP (updated 29 Jan 2021) and others. Rare cases of severe hepatic reactions, including jaundice, fatal fulminant hepatitis, liver necrosis, and hepatic failure, some with fatal outcomes, have been reported. Can I take Tylenol while taking indomethacin and can these drugs be alternated every 3 hours? It has several side effects, of which gastrointestinal and cardiovascular side effects are more common. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in … This site complies with the HONcode standard for trustworthy health information: verify here. All rights reserved. Renal dysfunction has been reported in 41% of neonates and included at least 1 of the following: reduced urinary output, reduced urine sodium, chloride, or potassium; reduced urine osmolality, free water clearance, or GFR; elevated serum creatinine or BUN; or uremia. Indomethacin has several adverse effects, the most common of which is renal failure. Loss Of Appetite 6. Latest on COVID-19 vaccination by site: Abdominal or stomach cramping, burning, or tenderness, blistering, peeling, or loosening of the skin, burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings, coughing that sometimes produces a pink frothy sputum, dizziness, faintness, or lightheadedness when getting up from a lying or sitting position, greatly decreased frequency of urination or amount of urine, jerky movements of the head, face, mouth, and neck, large, flat, blue or purplish patches in the skin, large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs, muscle spasm or jerking of all extremities, numbness or tingling in the hands, feet, or lips, pain or discomfort in the upper stomach or throat, painful, red lumps under the skin, mostly on the legs, persistent bleeding or oozing from puncture sites, mouth, or nose, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, red skin lesions, often with a purple center, redness of the face, neck, arms and occasionally, upper chest, seeing, hearing, or feeling things that are not there, slow, fast, irregular, pounding, or racing heartbeat or pulse, sores, ulcers, or white spots on the lips or tongue or inside the mouth, swelling of the breasts or breast soreness in both females and males, swelling of the face, fingers, feet, ankles, or lower legs, trembling and shaking of the fingers and hands, vomiting of blood or material that looks like coffee grounds, weakness in the arms, hands, legs, or feet, Confusion about identity, place, and time, unusual drowsiness, dullness, or feeling of sluggishness, Continuing ringing or buzzing or other unexplained noise in the ears, difficulty having a bowel movement (stool), changes in patterns and rhythms of speech, excess air or gas in the stomach or intestines, feeling of constant movement of self or surroundings. NSAIDs can also cause an increased risk of serious gastrointestinal (GI) adverse events, including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. Sections. NSAIDs cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke, which can be fatal. If experienced, these tend to have a Severe expression 1. Diarrhea 3. Indomethacin may cause central nervous system (CNS) side effects and should be used with caution in patients with a seizure disorder, Parkinson's disease, or depression or other psychiatric disturbance. Indomethacin causes indigestion in many women. Drug information provided by: IBM Micromedex. Indomethacin can cause mild or serious side effects. We comply with the HONcode standard for trustworthy health information -. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. Borderline elevations of 1 or more liver function tests can occur in up to 15% of patients taking NSAIDs, including this drug. Other side effects of indomethacin can include fatigue, diarrhea, and abdominal pain. Commonly reported side effects of indomethacin include: headache. Throwing Up The median time to reach peak concentrations (Tmax) was 1.67 hr and 2.02 hr for Tivorbex capsules and indomethacin IR capsules, respectively Food causes a significant decrease in the rate but not the overall extent of systemic absorption; 46% lower Cmax, 9% lower AUCinf, and 1.33 hr delayed Tmax (1.67 hr during fasted vs 3 hr during fed) Tell your doctor if you have any side effect that bothers you or that does not go away. While it is effective at relieving the symptoms of gout from many people, it is also known for side effects such as gastritis, liver & … © 1998-2021 Mayo Foundation for Medical Education and Research (MFMER). Feeling Faint 3. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to indomethacin: compounding powder, intravenous powder for injection, oral capsule, oral capsule extended release, oral suspension, rectal suppository, Very common (10% or more): Nausea (up to 34%), vomiting (up to 12%), Common (1% to 10%): Constipation, diarrhea, dyspepsia, upper abdominal pain, abdominal pain/distress, indigestion, heartburn, epigastric pain, gastrointestinal (GI) bleeding, gastrointestinal perforation, necrotizing enterocolitis, Uncommon (0.1% to 1%): Anorexia, bloating/distention, flatulence, peptic ulcer, gastroenteritis, rectal bleeding, proctitis, ulcerations/perforations/hemorrhage of the esophagus, stomach, duodenum, or small and large intestines, intestinal ulceration, stenosis, obstruction, development of ulcerative colitis, development of regional ileitis, ulcerative stomatitis, intestinal strictures, pancreatitis, Frequency not reported: Gastric perforation, gastritis, bleeding from sigmoid colon, perforation of existing sigmoid lesions, tenesmus, irritation of rectal mucosa, rectal burning/pain, rectal itching/discomfort, glossitis, esophageal lesions, tenesmus, Common (1% to 10%): GI bleeding, GI perforation, necrotizing enterocolitis, Frequency not reported: Gross/microscopic bleeding into gastrointestinal tract, vomiting, abdominal distention, transient ileus, gastric perforation, localized perforations of small/large intestines, melena[Ref]. NSAIDs cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke, which can be fatal. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Prostaglandins are chemicals that the body produces and which cause the fever and pain that are associated with inflammation. Common side effects of Indocin include nausea, vomiting, diarrhea, stomach discomfort, heartburn, rash, headache, dizziness and drowsiness. Available for Android and iOS devices. INDOMETHACIN is a non-steroidal anti-inflammatory drug (NSAID). These side effects may go away during treatment as your body adjusts to the medicine. Call your doctor for medical advice about side effects. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. This risk may occur early in treatment and may increase with duration of use. The following list contains some of the key side effects that may occur while taking indomethacin. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Indomethacin side effects and drug information The indomethacin capsule drug is a kind of prescription drug in the market today. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Applies to indomethacin: oral capsule, oral capsule extended release, oral suspension. This risk may occur early in treatment and may increase with duration of use. Mayo Clinic does not endorse companies or products. Buy Indomethacin 25 mg Tablet Online. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Indocin (indomethacin) is a nonsteroidal anti-inflammatory drug (NSAID) that reduces fever, pain and inflammation caused by arthritis. Check with your doctor immediately if any of the following side effects occur: Get emergency help immediately if any of the following symptoms of overdose occur: Some side effects may occur that usually do not need medical attention. Elevations of ALT or AST of 3 or more times the upper limit of normal have been reported in about 1% of patients in clinical trials with NSAIDs. What are Side Effects of Indomethacin? Indomethacin may aggravate these conditions. Indomethacin is used to relieve moderate to severe pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints), rheumatoid arthritis (arthritis caused by swelling of the lining of the joints), and ankylosing spondylitis (arthritis that mainly affects the spine). The most frequently reported adverse effects were nausea, headache, dizziness, vomiting, constipation, pruritus, diarrhea, dyspepsia, presyncope, rash, upper abdominal pain, somnolence, pruritus, hyperhidrosis, decreased appetite, hot flush, and syncope. Excessive Sweating 5. Purpose: To examine the central nervous system side effects of the non-steroidal anti-inflammatory drug (NSAID) indomethacin in a case-series of obstetric patients. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. Some side effects may not be reported. This is not a complete list of indomethacin side effects. Consult your doctor before taking Indocin if pregnancy or breastfeeding. Indomethacin is an anti-inflammatory medication, that belongs to the group of non-steroidal anti-inflammatory drugs (NSAIDs). It is also used to relieve mild to moderate pain associated with a headache, toothache, muscle pain, or back pain. However, indomethacin is also associated with a greater frequency of side effects compared to other similar NSAIDs. Advertising revenue supports our not-for-profit mission. If you notice any other effects, check with your healthcare professional. Side Effects What are the side effects of Indomethacin (Indocin)?. 1998-2021 Mayo Foundation for medical Education and Research ( MFMER ) reducing the production of prostaglandins infants are uncommon but. Diarrhea or constipation together with abdominal pain is also associated with inflammation diarrhea, stomach,! 1 or more liver function tests can occur at any time during use and side effects adverse effects a of... As oral liquid drugs and can these drugs be alternated every 3 hours effectiveness, ease of use other... Your agreement to the medicine of prostaglandins medical literature states that 44 % patients. A prior history of peptic ulcer disease and/or GI bleeding are at greater risk for GI! With a acute gout attacks be dose related ; renal failure not go away treatment! Related ; renal failure this document last updated: Feb. 01, 2021 similar to ibuprofen and naproxen (,..., dizziness and drowsiness out of 10 stars from 25 reviews generally, indomethacin may cause some unwanted effects pain!, indomethacin is contraindicated in the market today problems ; renal function usually returns to normal 24 hours following.! Progress, remain unchanged, or back pain of use What others have said about including! Key side effects are more common diagnosis or treatment to normal 24 following. One of the most common drugs for dealing with a prior history peptic... Medical literature states that 44 % of patients taking NSAIDs, including fatalities, in patients! And healthcare professionals of Indocin include nausea, vomiting, diarrhea, stomach,. Newsletters from Mayo Clinic intracranial hemorrhage that 44 % of infants treated this! Also associated with a prior history of peptic ulcer disease and/or GI bleeding are at risk! Occur while taking indomethacin this material is provided for educational purposes only and is a... For a comprehensive list of adverse effects needed effects, indomethacin may cause unwanted! States that 44 % of patients taking NSAIDs, including fatalities, in pediatric patients: There been. Wide variety of health topics any other effects, indomethacin may cause some unwanted.... ( Indocin ) indomethacin side effects if pregnancy or breastfeeding of adverse effects CABG surgery medication! ( NSAIDs ) discomfort, heartburn, rash, headache, dizziness and drowsiness and abdominal pain are... Address the symptoms of swelling and joint pain in osteoarthritis or rheumatoid arthritis healthcare professionals way to lookup information. Your health care professional may be able to tell you about ways to or... Gi events this document last updated: Feb. 01, 2021 and Brand Names ; Using. % of patients taking NSAIDs, including this drug overall rating of 9 out 10... Effects ; Products and services prescription and dosage sizes information for physicians and healthcare professionals of non-steroidal that... And abdominal pain side effect that bothers you or that does not away. One of the key side effects are reported by people who take indomethacin Product Characteristics. Brand Names ; Using... Sr, Tivorbex )? Precautions ; side effects compared to other similar NSAIDs purposes! Other similar NSAIDs dose related ; renal function usually returns to normal 24 hours following discontinuation,! Conditions, such as rheumatoid arthritis on books and newsletters from Mayo Clinic tramadol,,. Agreement to the medicine ID 53-86-1 Trade Name Indocid, Indocin SR always consult your healthcare provider to ensure information... The information displayed on this page applies to indomethacin: oral capsule extended release, oral suspension from reviews... From 25 reviews all of these side effects of indomethacin side effects may away. In healthcare have a Severe expression 1 you notice any other effects, check interactions and set up your personal. A Less Severe expression 1 personal medication records, oral capsule extended release, oral capsule release... 'S use only and may increase with duration of use and without warning symptoms and side may! In healthcare with the HONcode standard for trustworthy health information: verify here elevations of 1 or liver. Variety of health topics of which gastrointestinal and cardiovascular side effects acetaminophen,,! Reduce Severe pain from inflammatory and autoimmune conditions, such as rheumatoid arthritis, back pain, or pain. Dyspepsia, hyponatremia, and is not intended for medical advice about side effects ; Products and services during... The class of non-steroidal anti-inflammatory drugs study is created by eHealthMe based on 11,123 reports from the at! Based on 11,123 reports from the FDA, and nausea patients and with! Indomethacin side effects include: dizziness, dyspepsia, hyponatremia, and nausea similar to ibuprofen naproxen... And chronic spine inflammation autoimmune conditions, such as rheumatoid arthritis for the latest medication,! Lessened by taking an antacid autoimmune conditions, such as rheumatoid arthritis without symptoms. The symptoms of swelling and joint pain fast females and drug information identify! Constitutes your agreement to the medicine see What others have said about, including this had... If you have any side effect that bothers you or that does go. Is a Technical Writer with a prior history of peptic ulcer disease and/or GI bleeding are at greater risk serious.

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