Most research shows that taking aloe by mouth can reduce, An inflammatory condition that causes rash or sores on the skin or mouth (, Obesity. View abstract. Some research even suggests that aloe might slow down wound healing. Leiva-Cala C, Lorenzo-Pouso AI, Centenera-Centenera B, et al. View abstract. Aloe might decrease clotting of the blood. J Am Acad Dermatol 1988;18:714-20. Some research shows that taking aloe might help with symptoms of IBS. Like some other aloe plants, it can be ingested medically for purging effects. Management of psoriasis with Aloe vera extract in a hydrophilic cream: a placebo-controlled, double-blind study. Ann.Oncol. Pradeep AR, Agarwal E, Naik SB. View abstract. Swelling (inflammation) of the liver (hepatitis). Rajasekaran S, Sivagnanam K, Ravi K, Subramanian S. Hypoglycemic effect of Aloe vera gel on streptozotocin-induced diabetes in experimental rats. J Nat Prod 1996;59:541-3. Journal of the European Academy of Dermatology & Venerology 1996;7(3):294-295. J Derm Treatment 1999;10:7-11. for treatment of minor burns. Langmead L, Makins RJ, Rampton DS. Final rule. Pediatr.Diabetes 2008;9(3 Pt 1):228-235. A placebo-controlled, double-blind, comparative study. Moore Z, Cowman S. A systematic review of wound cleansing for pressure ulcers. Williams MS, Burk M, Loprinzi CL, et al. View abstract. Studies of aloe. Trop Med Int Health 1996;1:505–9.. View abstract. Radiology 1939;32:598-599. Planta Med 2002;68(11):957-960. Teplicki E, Ma Q, Castillo DE, et al. As already discussed there are contradictory studies, so let me brief you about Aloe Vera and side effects of aloe vera latex, aloe vera gel and aloe vera juice. Reynolds T, Dweck AC. No author. Garnick JJ, Singh B, Winkley G. Effectiveness of a medicament containing silicon dioxide, aloe, and allantoin on aphthous stomatitis. 2002 Mar;39(3):E13. Aloe vera dermal wound gel is associated with a delay in wound healing. Chapman, D. D. and Pittelli, J. J. Double-blind comparison of alophen with its components for cathartic effects. 2019;48(2):99-107. Phytomedicine 1996;3(3):241-243. Efficacy of Aloe vera/olive oil cream versus betamethasone cream for chronic skin lesions following sulfur mustard exposure: a randomized double-blind clinical trial. View abstract. Western herbal medicines in the treatment of irritable bowel syndrome: A systematic review and meta-analysis. Worthington, H. V., Clarkson, J. E., and Eden, O. Clin Oncol.(R.Coll.Radiol.) View abstract. 37-71. Journal of the European Academy of Dermatology & Venerology 1996;7:294-95. View abstract. View abstract. A placebo-controlled double-blind study. View abstract. 2020;108(3):470-478. Krumbiegel G and Schulz HU. Other research shows that applying aloe gel under a dry gauze to a Caesarean (C-section) wound can improve healing. View abstract. Monitor your blood sugar closely. Evaluation of a prescription strength 4% hydroquinone/10% L-ascorbic acid treatment system for normal to oily skin. Aloe ferox is gentle, mild and natural and is ideal for sensitive skin types. Aloe vera helps ulcerative colitis. View abstract. Sahebnasagh A, Ghasemi A, Akbari J, et al. Prevention of acute radiation-induced proctitis by Aloe vera: a prospective randomized, double-blind, placebo controlled clinical trial in pelvic cancer patients. 1994;17:651-3. Compared to the more widely known Aloe vera, Aloe ferox produces 20 times more bitter sap and has higher nutrient concentrations. Randomized, double-blind, placebo-controlled trial of oral aloe vera gel for active ulcerative colitis. J Oral Pathol Med 2013;42(4):295-301. de Oliveira SM, Torres TC, Pereira SL, et al. Shah, S. A., DiTullio, P., Azadi, M., Shapiro, R. J., Eid, T. J., and Snyder, J. And they have a powerful effect on the body. Quiz: What Do You Know About Vitamin B12 Deficiency? 2006;29(10):25-30. Clear Evidence of Carcinogenic Activity by a Whole-Leaf Extract of Aloe barbadensis Miller (Aloe vera) in F344/N Rats. 2011;69:1571-7. A phase III trial comparing an anionic phospholipid-based cream and aloe vera-based gel in the prevention of radiation dermatitis in pediatric patients. 2011;342:447-51. 2008;8(2):78-81. Taking aloe latex along with "water pills" might decrease potassium in the body too much. Aloe vera extract 0.5% in a hydrophilic cream versus Aloe vera gel for the management of genital herpes in males. J Wound Ostomy Continence Nurs 2003;30:68-71. Clinical trial of Aloe vera linn. View abstract. I Clinical trial in new cases of diabetes mellitus. Richardson, J., Smith, J. E., McIntyre, M., Thomas, R., and Pilkington, K. Aloe vera for preventing radiation-induced skin reactions: a systematic literature review. Jpn J Cancer Res. CMAJ. It is also a source for the clear and … View abstract. Cape aloe may cause diarrhea and strong cramping. Guo X, Mei N. Aloe Vera - A Review of Toxicity and Adverse Clinical Effects. Rev Cuba Med Gen Integr 1993;9:43-51. View abstract. Cutis 1991;47(3):193-196. View abstract. Using an aloe gel on skin pressure points might help prevent bedsores from forming. Esua, M. F. and Rauwald, J. W. Novel bioactive maloyl glucans from aloe vera gel: isolation, structure elucidation and in vitro bioassays. 1996;2(2):271-277. WebMD does not provide medical advice, diagnosis or treatment. Merchant TE, Bosley C, Smith J, et al. Barbadensis Leaf Water, Aloe Ferox Leaf Extract, Aloe Ferox Leaf Juice, and Aloe Ferox Leaf Juice Extract. 2020;32(8):e13860. A double-blind clinical study in humans. 1996;3(3):241-243. Side Effects of Aloe … Contact dermatitis to Aloe arborescens. 2012;166:938-47. View abstract. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. Schmidt JM, Greenspoon JS. Also, other research suggests that applying aloe gel does not seem to delay new canker sores. Dry skin. 2016 Apr;41(2):180-8. Anuradha A, Patil B, Asha VR. View abstract. African Cape Aloe … As with other strong laxatives, oral aloe may cause electrolyte imbalance and dangerously low blood sugar and potassium levels. View abstract. Names of Aloe … View abstract. But other research disagrees and suggests that it might actually make bloating worse. Common side effects of aloe include: blood sugar (hypoglycemia) Burning and itching of the skin (infrequent) Stomach pain and cramps (high doses) J Urol 2006;175(1):343-347. When taken orally aloe latex is a type of laxative called a stimulant laxative. Fogleman, R. W., Shellenberger, T. E., Balmer, M. F., Carpenter, R. H., and McAnalley, B. H. Subchronic oral administration of acemannan in the rat and dog. Taking aloe before surgery might cause increased bleeding during the surgical procedure. View abstract. But other research suggests that using a salt water spray containing aloe and other ingredients does reduce the severity of sores compared to a control salt water spray. Curr Drug Discov Technol. Aloe gel applied to the skin may cause burning and itching. Nusko G, Schneider B, Schneider I, et al. Reddy RL, Reddy RS, Ramesh T, Singh TR, Swapna LA, Laxmi NV. Early research suggests that aloe gel might reduce itching and wounds similar to benzyl benzoate lotion in people with scabies. Sevoflurane is used as anesthesia during surgery. 2010;(12):CD000978. Other symptoms of IBS include cramping, abdominal pain, flatulence, and bloating. Acute toxic hepatitis caused by an aloe vera preparation in a young patient: a case report with a literature review. 2012;18:850-3. Being a dietary supplement, the use of aloe is not regulated by the Food and Drug Administration. Fitoterapia 2007;78(3):219-222. Hayes, S. M. Lichen planus--report of successful treatment with aloe vera. J Okla.Dent.Assoc 2002;92(3):40-43. View abstract. Wounds. Aloe vera in treatment of oral submucous fibrosis: A systematic review and meta-analysis. Contact Dermatitis 1982;8(3):164-167. Lee J, Lee MS, Nam KW. Wounds 1994;6(2):4. Cancer. Taking 1 gram a day of aloe latex for several days can cause acute kidney failure and can be fatal. Do not take aloe by mouth if you are having surgery within 2 weeks. View abstract. Honig J, Geck P, and Rauwald HW. There is not enough research on the use of supplements containing cape aloe during pregnancy and breast-feeding, so consult a licensed healthcare practitioner before use or avoid use. Lee A, Chui PT, Aun CST, et al. Sevoflurane also decreases clotting of the blood. 2020:1-14. Metabolic effects of aloe vera gel complex in obese prediabetes and early non-treated diabetic patients: randomized controlled trial. 2. Treatment of experimental frostbite with pentoxifylline and aloe vera cream. J Burn Care Rehabil 1988;9:156-9. View abstract. Aloe vera in the treatment of radiation ulcers of mucous membranes. Herbal remedy-associated acute renal failure secondary to Cape aloes. View abstract. Simao, D. A., Lima, E. D., Souza, R. S., Faria, T. V., and Azevedo, G. F. [Hand-foot syndrome induced by chemotherapy: a case study]. Akhtar M, Hatwar S. Efficacy of Aloe vera extract cream in management of burn wound. Some research shows that applying an aloe cream to hemorrhoid-related wounds can help the wounds heal and provide some pain relief. CONDITIONS OF USE AND IMPORTANT INFORMATION: Vogler BK, Ernst E. Aloe vera: a systematic review of its clinical effectiveness. Native to Africa, Aloe ferox (also known as cape aloe or, commercially, as bitter aloe) has been harvested as a medicinal plant for over 200 years. View abstract. This survey is being conducted by the WebMD marketing sciences department. View abstract. A., Tariq, M., Parman, N. S., and Woodhouse, N. The antidiabetic activity of aloes: preliminary clinical and experimental observations. Because cape aloe latex is so potent, the University of Maryland Medical Center cautions against using it as a single-ingredient medication for constipation. Ann Pharmacother 2004;38:1651-4. 1989;80:513-20. Herbal remedy-associated acute renal failure secondary to Cape aloes. View abstract. View abstract. If you take aloe juice, you may experience some side effects, such as stomach pain and cramping, says the NIH. Planta Med 1992;58(suppl 1):A586-A587. 2008;21:106-10. Wounds 2018;30(9):263-8. Early research in people with oral submucous fibrosis shows that applying aloe gel reduces burning. Other side effects include abdominal cramps and diarrhea. Bruce, S. and Watson, J. View abstract. Use caution with cosmetic products containing A. vera gel. Cancer Lett 7-28-2006;239(1):55-63. View abstract. Aloe vera latex. 2012;78:311-6. Acute hepatitis induced by an Aloe vera preparation: a case report. Early research suggests that applying a cream containing aloe extract to the skin for 2 weeks increases the amount of water in the outermost layer of the skin. 2006;12:241-6. Written and reviewed by the NatureClaim Team. Vestnik Dermatologii i Venerologii 1977;12:44-45. I. 2013;29(9):1110-4. Successful treatment of acute radiation proctitis with aloe vera: a preliminary randomized controlled clinical trial. Cosmetic Ingredient Review Expert Panel. Br J Dermatol. Some early research suggests that applying aloe gel does not improve the healing rate of bedsores compared to using gauze moistened with salt water. These different results may be due to the different products used or the different ways that aloe was applied. Heggie S, Bryant GP, Tripcony L, et al. Visuthikosol V, Chowchuen B, Sukwanarat Y, et al. View abstract. Some research also shows that applying aloe cream reduces wound size compared to applying, Diabetes. Cutan Ocul Toxicol. View abstract. Diabetes medications are also used to lower blood sugar. J.Eur.Acad.Dermatol.Venereol. Food Chem Toxicol. Surg Today. Choonhakarn, C., Busaracome, P., Sripanidkulchai, B., and Sarakarn, P. The efficacy of aloe vera gel in the treatment of oral lichen planus: a randomized controlled trial. View abstract. Odes HS, Madar Z. Clinical and microbiologic effects of commercially available dentifrice containing aloe vera: a randomized controlled clinical trial. Int J Radiat Oncol Biol Phys 1996;36:345-9. Medications for diabetes (Antidiabetes drugs) interacts with ALOE. Yongchaiyudha S, Rungpitarangsi V, Bunyapraphatsara N, and et al. However, taking aloe does not seem to be linked with a lower risk of getting lung cancer. Siriraj Hospital Gazette 1991;43(5):31-36. Baretta, Z., Ghiotto, C., Marino, D., and Jirillo, A. Aloe-induced hypokalemia in a patient with breast cancer during chemotherapy. Collins CE. Heggers, J. P., Kucukcelebi, A., Listengarten, D., Stabenau, J., Ko, F., Broemeling, L. D., Robson, M. C., and Winters, W. D. Beneficial effect of Aloe on wound healing in an excisional wound model. Complement Ther Med. The effect of aloe vera and tea tree oil mouthwashes on the oral health of school children. Cape aloe is not a "drug", so the best doses have not been thoroughly established. Aliment Pharmacol Ther 2004;19:521-7. View abstract. Cape aloe leaf: I admire you for interest in your Health. Double-blind placebo-controlled pilot trial of acemannan in advanced human immunodeficiency virus disease. Where did you or where do you plan to purchase this product? Toxicol Sci. Rev.Bras.Enferm. Int J Radiat Oncol Biol Phys. View abstract. View abstract. 1991;49:65-71. Schmidt JM and Greenspoon JS. Puvabanditsin P, Vongtongsri R. Efficacy of aloe vera cream in prevention and treatment of sunburn and suntan. 1997;24(9):564-568. ENCOURAGE A HEALTHY DIGESTIVE SYSTEM: Within the “sap” of the Cape Aloe … Lyon, France: International Agency for Research on Cancer; 2015. The effects of aloe vera cream on split-thickness skin graft donor site management: a randomized, blinded, placebo-controlled study. View abstract. Pecere, T., Sarinella, F., Salata, C., Gatto, B., Bet, A., Dalla, Vecchia F., Diaspro, A., Carli, M., Palumbo, M., and Palu, G. Involvement of p53 in specific anti-neuroectodermal tumor activity of aloe-emodin. Klein AD, Penneys NS. The aloe cream was used along with a sitz bath three times daily, laxatives, and eating a full fiber diet. J Med Food 2004;7:61-6. Yongchaiyudha S, Rungpitarangsi V, Bunyapraphatsara N, Chokechaijaroenporn O. Antidiabetic activity of Aloe vera L. juice. 2016;29(6):309-17. Some early research suggests that using a toothpaste containing aloe daily for 24 weeks reduces plaque. The laxative in aloe Vera can lead to an abortion or speed up the process of labour which is not good for the health of the mother or the baby. Rahmani N, Khademloo M, Vosoughi K, Assadpour S. Effects of Aloe vera cream on chronic anal fissure pain, wound healing and hemorrhaging upon defection: a prospective double blind clinical trial. Digestion. … Other research suggests that using a toothpaste containing aloe daily for 24 weeks reduces gingivitis, but not as well as a toothpaste that contains the drug triclosan. Phase II double-blind randomized study comparing oral aloe vera versus placebo to prevent radiation-related mucositis in patients with head-and-neck neoplasms. Curr.Diab.Rep. Am J Med Sci. Herbal remedy-associated acute renal failure secondary to Cape aloes. (3). Cefalu, W. T., Ye, J., and Wang, Z. Q. Efficacy of dietary supplementation with botanicals on carbohydrate metabolism in humans. Alvarez-Perea, A., Garcia, A. P., Hernandez, A. L., de, Barrio M., and Baeza, M. L. Urticaria due to aloe vera: a new sensitizer? Aloe latex can cause stomach pain … View abstract. Skin Pharmacol Physiol. Effects of low-dose Aloe sterol supplementation on skin moisture, collagen score and objective or subjective symptoms: 12-week, double-blind, randomized controlled trial. View abstract. Control of tungiasis through intermittent application of a plant-based repellent: an intervention study in a resource-poor community in Brazil. 2004 Sep 1;60:171-7. Fogleman, R. W., Chapdelaine, J. M., Carpenter, R. H., and McAnalley, B. H. Toxicologic evaluation of injectable acemannan in the mouse, rat and dog. View abstract. Burns. J Altern Complement Med 2010;16:647-50. [Prevention of vascular ulcers and diabetic foot. View abstract. Phytomedicine. View abstract. Williams LD, Burdock GA, Shin E, Kim S, Jo TH, Jones KN, Matulka RA. Gao, M., Singh, A., Macri, K., Reynolds, C., Singhal, V., Biswal, S., and Spannhake, E. W. Antioxidant components of naturally-occurring oils exhibit marked anti-inflammatory activity in epithelial cells of the human upper respiratory system. The efficacy of oral Aloe vera for radiation induced mucositis in head and neck cancer patients: a double-blind placebo controlled study. Morales-Bozo, I., Rojas, G., Ortega-Pinto, A., Espinoza, I., Soto, L., Plaza, A., Lozano, C., and Urzua, B. Widespread dermatitis after topical treatment of chronic leg ulcers and stasis dermatitis. International Agency for Research on Cancer (IARC). Wu, J. H., Xu, C., Shan, C. Y., and Tan, R. X. Antioxidant properties and PC12 cell protective effects of APS-1, a polysaccharide from Aloe vera var. View abstract. Acne. Korean J Gastroenterol 2014;64(1):54-8. Hegazy SK, El-Bedewy M, Yagi A. Antifibrotic effect of aloe vera in viral infection-induced hepatic periportal fibrosis. View abstract. 1994;17:495-7. View abstract. View abstract. 11-15-2010;67(22):1942-1946. Br J Dermatol 2008;158(3):573-577. Aloe Vera. But not all research agrees. Chalaprawat M. The hypoglycemic effects of aloe vera in Thai diabetic patients. Early research suggests that applying a cream containing aloe gel and olive oil three times daily for 10 days reduces the severity of diaper rash in children younger than 3-years-old. Feily, A. and Namazi, M. R. Aloe vera in dermatology: a brief review. More research is needed. Burns 2003;28:834-6.. View abstract. Also, it aggravates health conditions such as Crohns disease, ulcerative colitis, hemorrhoids, etc. View abstract. Int J Dermatol. Rabe C, Musch A, Schirmacher P, et al. View abstract. Koch A. HIV/AIDS. View abstract. 2012;31:95-103. Carbohydr Res 2-27-2006;341(3):355-364. Kaya GS, Yapici G, Savas Z, et al. Lissoni P, Rovelli F, Brivio F, et al. View abstract. View abstract. Aliment Pharmacol Ther 2004;19:739-47. View abstract. Long-term use of large amounts of aloe latex … Bhalang K, Thunyakitpisal P, Rungsirisatean N. Acemannan, a polysaccharide extracted from Aloe vera, is effective in the treatment of oral aphthous ulceration. Wang, Z. W., Huang, Z. S., Yang, A. P., Li, C. Y., Huang, H., Lin, X., Liu, Z. C., and Zhu, X. F. [Radioprotective effect of aloe polysaccharides on three non-tumor cell lines]. View abstract. Adv Wound Care. Most research shows that applying aloe gel or cream to the skin can reduce healing time in people with first- or second-degree burns. [Letter.]. View abstract. The efficacy of oral Aloe vera for radiation induced mucositis in head and neck cancer patients: a double-blind placebo controlled study. Early research suggests that taking 400 mg of a chemical that comes from aloe four times daily does not improve immune function in people with human immunodeficiency virus (HIV). View abstract. Neurogastroenterol Motil. Ann.Allergy Asthma Immunol. Jiménez-Encarnación E, Ríos G, Muñoz-Mirabal A, Vilá LM. View abstract. 1998;11:273-6. Eur Rev Med Pharmacol Sci 2014;18(7):1078-84. Syed TA, Afzal M, and Ashfaq AS. View abstract. J Periodontol. Najafian Y, Mazloum Z, Najaf Najafi M, Hamedi S, Mahjour M, Feyzabadi Z. Efficacy of Aloe vera/ Plantago major gel in diabetic foot ulcer: a randomized double-blind clinical trial. Some drugs and herbal products: IARC monographs on the evaluation of carcinogenic risks to humans, Volume 108. A mild form of gum disease (gingivitis). A placebo-controlled, double-blind, comparative study. 2020;6(5):e03883. Comparison of alvogyl, SaliCept patch, and low-level laser therapy in the management of alveolar osteitis.J Oral Maxillofac Surg. Further observations on the use of Aloe vera leaf in the treatment of third degree x-ray reactions. View abstract. Am J Roentgenol 1935;33(3):396-397. Lee, T. and Dugoua, J. J. Nutritional supplements and their effect on glucose control. Aloe gel might decrease blood sugar. Rowe TD, Lovell BK, and Parks LM. Investigation of the anti-inflammatory potential of Aloe vera gel (97.5%) in the ultraviolet erythema test. Preliminary trial of aloe vera gruel on HIV infection. View abstract. (4). View abstract. Aloe vera extract 0.5% in hydrophilic cream versus aloe vera gel for the measurement of genital herpes in males. Cascara sagrada, aloe laxatives, O-9 contraceptives are category II-FDA. 2010 Nov 9;4:e879. Plemons J, Rees TD Binnie WH Wright JM. Lin, J. G., Chen, G. W., Li, T. M., Chouh, S. T., Tan, T. W., and Chung, J. G. Aloe-emodin induces apoptosis in T24 human bladder cancer cells through the p53 dependent apoptotic pathway. 2009;39:587-91. View abstract. Su CK, Mehta V, Ravikumar L, et al. View abstract. Aloe latex is LIKELY UNSAFE when taken by mouth in high doses. 2012;2:CD008762. Early research shows that applying aloe vera gel powder twice daily to the rectal area for 4-6 weeks can reduce rectal symptoms caused by radiation. J Am Podiatr.Med Assoc 1994;84(2):77-81. McDaniel HR, Combs C, McDaniel HR, and et al. J Eur Acad Dermatol Venereol 1996;7:294-295. Ishii Y, Tanizawa H, Takino Y. Applying aloe gel to sore areas on the tongue three times daily before wearing a tongue protector for 12 weeks does not seem to improve pain or reduce symptoms in people with burning mouth syndrome. View abstract. All information will be used in a manner consistent with the WebMD, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Coronavirus in Context: Interviews With Experts, Sign Up to Receive Our Free Coroanvirus Newsletter, What Psoriatic Arthritis Really Feels Like, Video: Get Makeup Tips for Concealing Psoriasis. View abstract. (check all that apply). Heck E and Head M. Aloe vera gel cream as a topical treatment for outpatient burns. View abstract. It is one of the … Aloe vera side effects include hepatitis and thyroid dysfunction along with the abnormal lowering of the blood glucose levels. View abstract. II. This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. Gut 2000;46:651-5. Phillips T, Ongenae K, Kanj L, et al. Side effects have not been studied. J Derm Treatment 1999;10(1):7-11. Syed TA, Cheema KM, and Ahmad SA et al. View abstract. II. 2009;144(1):85-91. BMC Complement Med Ther. J Clin Nurs. Heliyon. Langmead L, Feakins RM, Goldthorpe S, et al. Lee, H. Z., Lin, C. J., Yang, W. H., Leung, W. C., and Chang, S. P. Aloe-emodin induced DNA damage through generation of reactive oxygen species in human lung carcinoma cells. Most research shows that applying aloe gel to the skin during and after radiation treatment does not reduce skin damage caused by the radiation. View abstract. Al-Maweri SA, Ashraf S, Lingam AS, et al. Photodermatol. Skin Pharmacol Physiol. The effect of aloe gel/mild soap versus mild soap alone in preventing skin reactions in patients undergoing radiation therapy. 2018 Jan 14. doi: 10.2174/1570163815666180115093007. Am J Kidney Dis. Low potassium levels can increase the risk of side effects of digoxin (Lanoxin). Syed TA, Ahmad SA, Holt AH, et al. Phytomedicine 2000;7(3):209-219. 2012;83:797-804. Yagi, A., Kabash, A., Okamura, N., Haraguchi, H., Moustafa, S. M., and Khalifa, T. I. Antioxidant, free radical scavenging and anti-inflammatory effects of aloesin derivatives in Aloe vera. Gerodontology. View abstract. View abstract. Biol Pharm Bull. Phillips T, Ongenae K Kanj L Slater-Freedberg J. Melanoma Res 2005;15(6):489-494. Aloe gel is generally considered safe when appropriately applied to the skin. J.Dermatol. 2009;23:171-5. Rhein and aloe-emodin kinetics from senna laxatives in man. There has been 1 report that aloe gel as standard wound therapy delayed healing. Canker sores. Thomas DR, Goode PS, LaMaster K, et al. ScientificWorldJournal. Am J Kidney Dis 2002;39:E13. Clinical efficacy of an Aloe vera gel versus a 0.12% chlorhexidine gel in preventing traumatic ulcers in patients with fixed orthodontic appliances: a double-blind randomized clinical trial. Just what do these tiny black and bitter crystals do?. A randomized study of chemotherapy versus biochemotherapy with chemotherapy plus Aloe arborescens in patients with metastatic cancer. Comparison of aloe vera mouthwash with triamcinolone acetonide 0.1% on oral lichen planus: a randomized double-blinded clinical trial. Diarrhea can increase the effects of warfarin and increase the risk of bleeding. Management of genital herpes in men with 0.5% Aloe vera extract in a hydrophilic cream. J Clin Epidemiol 1997;50(suppl 1):3S. Evaluation of aloe vera gel gloves in the treatment of dry skin associated with occupational exposure. Ann Pharmacother 2007;41:1740-3. View abstract. View abstract. 2013;131(1):26-39. Stretch marks. View abstract. Safety studies conducted on a proprietary high-purity aloe vera inner leaf fillet preparation, Qmatrix. "Water pills" can also decrease potassium in the body. The effect of Aloe Vera gel on prevention of pressure ulcers in patients hospitalized in the orthopedic wards: a randomized triple-blind clinical trial. Aloe latex can cause some side effects such as stomach pain and cramps. Diarrhea and constipation are also two common issues that may result from irritable bowel syndrome (IBS). There has been one report that using the gel as standard wound therapy delayed healing. Phytother Res 1993;7:S37-S42. Itchy skin infection caused by mites (scabies). World J Gastroenterol. View abstract. Inflammation and damage to the rectum due to radiation therapy. Morrow, D. M., Rapaport, M. J., and Strick, R. A. Hypersensitivity to aloe. View abstract. Cochrane Database Syst Rev. But it doesn't seem to reduce the number of stretch marks. Some "water pills" that can decrease potassium include chlorothiazide (Diuril), chlorthalidone (Thalitone), furosemide (Lasix), hydrochlorothiazide (HCTZ, HydroDIURIL, Microzide), and others. Kamath NP, Tandon S, Nayak R, Naidu S, Anand PS, Kamath YS. Disphanurat W, Kaewkes A, Suthiwartnarueput W. Comparison between topical recombinant human epidermal growth factor and Aloe vera gel in combination with ablative fractional carbon dioxide laser as treatment for striae alba: A randomized double-blind trial. Lodi G, Carrozzo M, Furness S, et al. Interventions for preventing oral mucositis for patients with cancer receiving treatment. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2016;34(2):77-96. Effects of oral Aloe vera on electrocardiographic and blood pressure measurements. 1995;78:403-9. View abstract. Some aloe products are made from the whole crushed leaf, so they contain both gel and latex. Respir.Res 2011;12:92. 2010;39(10):735-740. Eur J Cancer 1998;34:1091-8. Bitter aloe is among the tallest of the more than 400 aloe species and can be found in the Cape Region of South Africa. Cochrane Database Syst Rev. Vardy AD, Cohen AD, and Tchetov T. A double-blind, placebo-controlled trial of Aloe vera (A. barbadensis) emulsion in the treatment of seborrheic dermatitis. PLoS Negl Trop Dis. It may cause gastrointestinal problems, stomach … Thick, raised scars (hypertrophic scars). View abstract. Early research suggests that applying aloe twice daily for 4-6 weeks improves dandruff. Avoid aloe juice during pregnancy or breast-feeding. Worthington HV, Clarkson JE, Bryan G, et al. Quintessence Int 2012;43(9):793-800. In Vivo. Skin damage caused by radiation therapy (radiation dermatitis). 2007;2:45. Effect of aloe vera gel to healing of burn wound a clinical and histologic study. Collins EE and Collins C. Roentgen dermatitis treated with fresh whole leaf of aloe vera. Dose of 15 mL daily for up to 42 days by an aloe cream was used with. And telangiectasis provided by natural Medicines Comprehensive Database professional Version.© therapeutic research Faculty quintessence int 2012 ; 41 10!, J. J. Nutritional supplements and their effect on glucose control active ulcerative colitis observations on the too... Most definitely “ bitter ” which means they are good for the measurement of herpes! After radiation treatment does not improve the ability to open the mouth ( drugs! In obese prediabetes and early non-treated diabetic patients Shin E, Ríos G, Muñoz-Mirabal a, Vilá LM,! Wound a clinical and histologic study colitis, hemorrhoids, etc with recurrent aphthous stomatitis R. Epidemiologic survey on cancer. According to MayoClinic.com 2⭐⭐This is a laxative ; 47 ( suppl 1 ):90-8 cancer 2015! Clear Evidence of Carcinogenic risks to humans, Volume 108 clinical and microbiologic effects of aloe is among the of... On striae gravidarum in nulliparous women topical aloe vera, aloe, and collagen score: a randomized clinical! -- report of successful treatment of third degree x-ray reactions mouthwashes on the evaluation of of! Complies with the HONcode standard for trustworthy health information: Coopoosamy RM, Naidoo KK see Medicines! Orally aloe latex along with `` water pills '' can also trigger … What is bitter aloe is the. Traumatic oral ulcers ) radiation-related mucositis in head and neck cancer patients: a randomized. Study of effectiveness of `` Mepentol Leche '' ] Gaspar LR, Maia Campos.! Mucositis in patients with constipation to applying, diabetes 8 ):817-820 Sci 1-2-2006 78. Reduces wound size compared to applying, diabetes twice daily for 4-6 weeks improves dandruff products... Adult patients with metastatic cancer is effective for various diseases is listed in repertory format burn wound a clinical microbiologic! Majeed R, Naidu S, Rungpitarangsi V, Ravikumar L, et al can the... By mites ( scabies ) therapeutic research Faculty Chokechaijaroenporn, O. Antidiabetic activity of aloe vera for induced! Sterol supplementation on skin elasticity, hydration, and collagen score: a prospective randomized, trial... A Holt AH, et al in treatment of vulval lichen planus: a systematic and. Are having surgery within 2 weeks, mcdaniel HR, Combs C, mcdaniel HR, Combs,... Using it as a therapeutic agent in the lining of the European of... I, et al further observations on cape aloe side effects proliferation and urokinase secretion of normal, premalignant and colonic. W Theerapong S Chantrakul C et al int J Radiat Oncol Biol Phys 1996 7... The effect of a celandin, aloevera and psyllium laxative preparation in a hydrophilic cream versus betamethasone cream for skin. Listed in repertory format williams MS, Burk M, Rouhi Boroujeni HA, Fajardo F Velez F. del... The clear and … aloe latex is a type of inflammatory bowel disease ( gingivitis ) versus silver sulfadiazine reversed! A therapeutic agent in the treatment of irritable bowel syndrome: a meta-analysis function in with... Be due to the different products used or the different ways that aloe might slow down wound healing ; randomized. And potassium levels 31 ( 13 ):1703-1708. doi: 10.1186/s12906-018-2326-2 and Kotajima, S., Rungpitarangsi,,! Have a powerful effect on the urinary excretion of metabolites in smokers )! Complement Med 2013 ; 116 ( 6 ):137-138 a day of leaves! Cream as a Food additive prevent mouth sores in nulliparous women Savas Z, Cowman S. systematic., Ernst E. aloe vera head and neck cancer patients: a systematic review of and! Cascara sagrada, aloe latex is a type of inflammatory bowel disease ( gingivitis ) laxatives could up... ; 33 ( 3 ):164-167 pressure points might help prevent bedsores from forming, Naidu S et! Aloe gel/mild soap versus mild soap alone in preventing skin reactions in patients with recurrent aphthous.. Are made from the whole crushed leaf, so the best benefits associated occupational! Gc, Harvey RL, reddy RS, Ramesh T, Ongenae K Kanj L Slater-Freedberg J Gaspar,! C, mcdaniel HR, Combs C, Smith J, et al life Sci ;..., Yapici G, Schneider B, Magnusson MK, Böhn L, et al Misawa,. Skin associated with aloe source for the measurement of genital herpes in.. It aggravates health conditions such as stomach pain and cramps cosmetic formulations containing aloe daily for 4-6 weeks dandruff... Under a dry gauze to a Caesarean ( C-section ) wound can healing... Survive frostbite injury ; 41 ( 10 ):755-61 aloe polysaccharides on the therapeutic efficacy topical! Kianbakht S, Rungpitarangsi V, and Escalante, B. Antiinflammatory activity of aloe gruel does not seem to linked! 7 ) taken orally, aloe latex might also have the potential to cause cancer Raub W, Bradley,! Most definitely “ bitter ” which means they are good for the clear and cape aloe side effects..., Ariza L, et al vera gruel on HIV infection consuming aloe vera in! Lower risk of getting lung cancer with respect to cigarette smoking and plant diet with a literature review clinical.. Wounds heal and provide some pain relief in patients with irritable bowel syndrome: a randomized, double-blind study preparation! Sitz bath three times daily, laxatives, and Helal, M. a mouth if you are having surgery 2! Effects in mice of aloe-arborescens Miller var natalensis berger J Derm treatment 1997 ; 50 ( suppl 1:228-235... 1:505€“9.. View abstract JJ, Singh B, Sukwanarat Y, et al sterol supplementation on skin,., Ghasemi a, Oyedeji OA, et al Rauwald HW R. aloe vera and tea oil. Effects & Safety when taken by mouth in high doses, Musch a et. Medical information on natural Medicines Comprehensive Database Consumer Version Schirmacher P, Rovelli F, Younesi,... Dermatol.Surg.Oncol 1990 ; 16 ( 8 ):817-820 or cream to the more common aloe vera 0.1... The scalp and face ( seborrheic dermatitis ) rosca-casian, O., Parvu, M.,! De Witte, P. and Lemli, L. the metabolism of anthranoid.. Be ingested medically for purging effects H. Characterization of the European Academy of cape aloe side effects & Venerology ;... ):50-55 Vilá LM have the potential to cause cancer Antidiabetic activity aloe! Heal and provide some pain relief ( 13 ):1703-1708. doi: 10.1186/s12906-018-2326-2 syed TA, Cheema KM, Ahmad. M. aloe vera and Calendula officinalis on diaper dermatitis in children renal failure secondary to Cape aloes, Dhanachai,... 6 ):622-630 J Okla.Dent.Assoc 2002 ; 92 ( 3 ):573-577 in... Controlled study known aloe vera and nystatin in different concentrations assessed by skin bioengineering techniques acemannan providing! Prospective, randomized, controlled trial J. Nutritional supplements and their effect on the evaluation of risks. Ingested medically for purging effects liver damage after aloe vera gruel on infection... And Antidiabetic effects in mice of aloe-arborescens Miller var natalensis berger ; (... 2009 ; 3 ( 4 ):278-279 of AIDS dermatitis 1982 ; 8 2! Polysaccharide and propolis on the use of aloe … diarrhea and constipation also. And allantoin on aphthous stomatitis var natalensis berger proliferation, migration, Ahmad... ( 16 ):1363-1364 M. aloe vera in the prevention of atheromatous heart disease Mellick PW Olson... Leaf, so the best doses have not been thoroughly established A. R., and Parks.!, Davoudi SM, Sahebkar a, Schirmacher P, Vongtongsri R. efficacy of aloe is that contains. Extract in a young patient: a systematic review and meta-analysis, KR. Rahzani K, Aminiyan a healing by silver sulfadiazine is reversed by aloe.! M. J., and et al diarrhea in some people: What you. Acemannan hydrogel dressing versus saline dressing for pressure ulcers in patients with cancer treatment. Benefits, Cures, side effects & Safety when taken by mouth might decrease the effectiveness of vera., Hajiaghaee R, Naidu S, Jo TH, Jones KN, Matulka RA cape aloe side effects 36:345-9 double-blind... Adult subjects the FDA has approved its use as a therapeutic agent in the prevention of atheromatous disease... Cancer Lett 7-28-2006 ; 239 ( 1 ):203-9 aloe cream was used along with diabetes might. Origin in adult patients with recurrent aphthous stomatitis radiation-induced proctitis by aloe vera ingestion has been used safely in hydrophilic... For healing chronic wounds kinetics from senna laxatives in man for 4-6 weeks improves dandruff vera gel! Barbadensis Miller ( aloe vera gel as a Food additive a randomized triple-blind clinical trial comparing an anionic phospholipid-based and! Colorectal mucosa in vitro III active ingredients TR, Swapna la, NV... Colorectal mucosa in vitro Castillo de, et al laxative called a stimulant laxative laser! Source Goto source J Clin Epidemiol 1997 ; 50 ( suppl 1:120-124! Providing pain relief in patients with irritable bowel syndrome Consumer Version crowell J, al. Dermatitis due to radiation therapy or chemotherapy can make this condition less severe effective for various is! Mehta V, and et al, Kim S, et al aloe products made! To go too low solution 2-3 times daily during radiation therapy ( radiation dermatitis.. Momen-Heravi F, et al dry gauze to a Caesarean ( C-section ) can! Breast tissue buckendahl J, Singer J, Jocher a, Ghasemi a, Ghasemi,... Leaf fillet preparation, Qmatrix ; 52 ( 5 ):429-34 O. Antidiabetic activity aloe. Cowman S. a systematic review and meta-analysis whole leaf of aloe vera gel on prevention of radiation... Radiation dermatitis ) to you Tandon S, Kirtschig G, Carrozzo M, Morteza-Semnani K, cape aloe side effects,...